Pair Name	Bisdemethoxycucurmin, Rapamycin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	GPR161	hsa23432
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Activity	MTOR	hsa2475
	Down-regulation	Activity	RPS6KB1	hsa6198
	Down-regulation	Expression	TWIST1	hsa7291
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	BT-549	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_1092
	BT-20	Invasive breast carcinoma	Homo sapiens (Human)	CVCL_0178
Result	Bisdemethoxycurcumin Promotes Apoptosis and Inhibits the Epithelial-Mesenchymal Transition through the Inhibition of the G-Protein-Coupled Receptor 161/Mammalian Target of Rapamycin Signaling Pathway in Triple Negative Breast Cancer Cells.